CLINICAL PATHOGENESIS OF TYPHOID FEVER

Clinical pathogenesis of typhoid fever

Clinical pathogenesis of typhoid fever

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Human infections with Salmonella enterica results in two major groups of diseases: gastroenteritis and typhoid fever.Clinical observations suggest that gastroenteritis, caused by non-typhoidal Salmonella serovars, is characterized by a massive neutrophil influx, Kitchen Cart which keeps the infection localized to the intestinal mucosa.In contrast, the absence of neutrophilic intestinal infiltrates in the acute phase of typhoid fever suggests a propensity for typhoidal Salmonella serovars (S.Typhi, S.

Paratyphi A, S.Paratyphi B and S.Paratyphi C) to evade aspects of the innate immune response and cause a systemic infection.The fact that there are no virulence genes shared by typhoidal Salmonella serovars that are absent from non-typhoidal Salmonella serovars, suggests that this innate immune evasion is mediated by different mechanisms in different typhoidal serovars.

This review discusses what is Garnish Stations / Bar Caddies known about the clinical pathogenesis of typhoid fever.

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